Burnham will promise “bold and honest” leadership, saying he will outline policies and commitments that form a “serious prospectus” for Britain and offer people more control over their lives.
He is expected to say that he initially wanted to “give the usual tub-thumping conference speech” but that “the patriot in me tells me something very different is needed”.
The prime minister has made “hope” the overall message of the four-day gathering.
It comes ahead of a tricky Budget at the end of next month, where the room for manoeuvre facing the prime minister has been narrowed by recent rises to the cost of UK borrowing.
Ahead of the speech, the prime minister has promised to reveal details of how he intends to fund his plans to provide free social care services to everyone in England.
He has said he wants to put his his plans before voters at the next general election, which legally must be held by August 2029 at the latest, before aiming to roll out the new system from 2030.
There has been speculation that in his efforts to free up future funding for his social care plans, the prime minister could question the long-term sustainability of the “triple lock” uprating policy for the state pension.
The policy – under which pension payments rise annually by the highest of 2.5%, inflation, or average wage rises – is expected to add billions to the cost of pensions in future years because of the UK’s ageing population.
Downing Street would not be drawn on whether a review is being considered, while ministers have been clear that a manifesto commitment to keep the triple lock for the duration of this parliament stands.
On Monday, Chancellor John Healey declined to guarantee the promise – which has featured in every Labour manifesto since 2015 – would feature in the party’s blueprint for voters at the next election.
“The manifesto will be the manifesto at the time, I’m not going to do that now,” he told BBC Radio 5 Live.
Sharon Graham, general secretary of the Unite union, issued a pre-emptive warning that scrapping the triple lock would be “electoral suicide”.
