The most obvious candidate to come into midfield is Jorginho.

Last season, the Italy midfielder played more successful passes into the final third per 90 minutes than any other Arsenal player (average 23.9), and his ability to play accurate passes over the top could be an asset against Tottenham’s high line.

Leandro Trossard could fill Odegaard’s role behind Kai Havertz, which may allow Raheem Sterling to make his debut as part of the three behind the striker along with Bukayo Saka.

“No coach likes it when you miss one or two of the most important players in your team,” former Arsenal midfielder Cesc Fabregas told the Planet Premier League podcast.

“When Manchester City or Liverpool miss top players they still deal with it in the best manner but not really missing them and Arsenal need to get to this level as well.

“I can’t remember an Arsenal game in the last two or three seasons without Odegaard in the team and more recently Rice.

“They are important players but big teams are made of big squads and they will need to prove they are ready to challenge the difficult moments as well.”

There has also been talk 17-year-old midfielder Ethan Nwaneri could play a part for the Gunners on Sunday.

“I have no doubts if Mikel puts him in the starting 11 or even during the game, it’s because he’s seen that he’s good enough to make an impact,” added Fabregas.

“Obviously, the consequences of Rice and Odegaard being out makes it a little bit faster than maybe what he would have liked.

“If he’s part of the squad, it’s because he [Arteta] really believes he can bring something to the table.”