The Caf appeals board ruled Senegal forfeited the Afcon final in Rabat on 18 January after several members of the side walked off the pitch in protest at a penalty awarded to Morocco in second-half stoppage time.
The Teranga Lions eventually returned and, after a delay of around 17 minutes, the resulting spot-kick taken by Brahim Diaz was saved and Senegal won 1-0 after extra time.
The decision by the Caf appeals board on 17 March has left African football’s governing body facing a crisis of confidence, with Veron Mosengo-Omba stepping down as the organisation’s general secretary on 29 March.
Motsepe says he has “zero tolerance” of corruption in any walk of life, describing it as “worse than Covid and cancer”.
“Whilst I am president of Caf we will never conceal any corruption,” he added.
“It is the biggest problem, not just in football. I have been told there have been lots of problems in the past [with corruption] and we intervened.
“We can’t set a bad example in football, to give our children the perception that if you want to succeed in life, be corrupt.
“That’s the best gift we can give football in Africa. Not just talking about corruption, but intervene, put the necessary laws [in place] and implement them.”
